Enantioselective total synthesis of FD-891

被引：42

作者：

Crimmins, MT ^{[1
]}

Caussanel, F ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Venable & Kenan Labs Chem, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 10期

关键词：

D O I：

10.1021/ja060018v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective synthesis of FD-891 has been achieved with a longest linear sequence of 21 steps. The synthetic strategy involves the use of aldol additions of a chlorotitanium enolate of N-acylthiazolidinethiones as the key reaction to establish 6 of the 10 stereogenic centers. A key cross-metathesis and a late-stage Julia olefination serve to assemble three key subunits. Copyright © 2006 American Chemical Society.

引用

页码：3128 / 3129

页数：2

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