Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates

被引：83

作者：

Agrawal, Toolika ^{[1
]}

Cook, Silas P. ^{[1
]}

机构：

[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 01期

关键词：

SUZUKI-MIYAURA; REAGENTS; CONSTRUCTION; AMINATION; CHLORIDES; ALKENYL; SUBSTITUTION; ACTIVATION; HALIDES; ARENES;

D O I：

10.1021/ol303130j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The iron-catalyzed cross-coupling of aryl sulfamates and tosylates has been achieved with primary and secondary alkyl Grignards. This study of iron-catalyzed cross-coupling reactions also examines the isomerization and beta-hydride elimination problems that are associated with the use of isopropyl nucleophiles. While a variety of iron sources were competent in the reaction, the use of FeF3 center dot 3H(2)O was critical to minimize nucleophile isomerization.

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页码：96 / 99

页数：4

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