New alkaloids from Cephalotaxus fortunei

被引：29

作者：

Bocar, M ^{[1
]}

Jossang, A ^{[1
]}

Bodo, B ^{[1
]}

机构：

[1] Museum Natl Hist Nat, CNRS, Lab Chim Substances Nat, ESA 8041, F-75005 Paris, France

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 01期

关键词：

D O I：

10.1021/np0203178

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new cephalotaxus alkaloids, cephalotaxine alpha-N-oxide (1), cephalotaxine beta-N-oxide (2), 11-beta-hydroxycephalotaxine beta-N-oxide (3), and isocephalotaxine (4), were isolated, together with several known alkaloids from an EtOAc extract of the fruits of Cephalotaxus fortunei. The structures were determined by spectral analysis including mass spectrometry and 2D NMR. Compounds 1, 2, 3, and 4 displayed cytotoxicity against nasopharynx KB cells with IC50 values of 30, 14, 31, and 15 mug/mL, respectively.

引用

页码：152 / 154

页数：3

共 13 条

[1]

ABRAHAM DJ, 1969, TETRAHEDRON LETT, P4085

[2]

Huang L., 1984, ALKALOIDS, V23, P157

[3] Cephalocyclidin A, a novel pentacyclic alkaloid from Cephalotaxus harringtonia var. nana [J].

Kobayashi, J ;

Yoshinaga, M ;

Yoshida, N ;

Shiro, M ;

Morita, H .

JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (07) :2283-2286

[4] MOLECULAR MECHANICS - THE MM3 FORCE-FIELD FOR HYDROCARBONS .2. VIBRATIONAL FREQUENCIES AND THERMODYNAMICS [J].

LII, JH ;

ALLINGER, NL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (23) :8566-8575

[5]

Miah M.A. J., 1998, The Alkaloids, V51, P199, DOI DOI 10.1016/S0099-9598(08)60006-1

[6] Cephalezomines A-F, potent cytotoxic alkaloids from Cephalotaxus harringtonia var. nana [J].

Morita, H ;

Arisaka, M ;

Yoshida, N ;

Kobayashi, J .

TETRAHEDRON, 2000, 56 (19) :2929-2934

[7] BIOSYNTHESIS OF THE CEPHALOTAXUS ALKALOIDS - INVESTIGATIONS OF THE EARLY AND LATE STAGES OF CEPHALOTAXINE BIOSYNTHESIS [J].

PARRY, RJ ;

CHANG, MNT ;

SCHWAB, JM ;

FOXMAN, BM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (03) :1099-1111

[8] ALKALOIDS OF CEPHALOTAXUS-HARRINGTONIA VAR DRUPACEA 11-HYDROXYCEPHALOTAXINE AND DRUPACINE [J].

POWELL, RG ;

MADRIGAL, RV ;

SMITH, CR ;

MIKOLAJCZAK, KL .

JOURNAL OF ORGANIC CHEMISTRY, 1974, 39 (05) :676-680

[9] New oxygenated Cephalotaxus alkaloids from Cephalotaxus harringtonia var drupacea [J].

Takano, I ;

Yasuda, I ;

Nishijima, M ;

Hitotsuyanagi, Y ;

Takeya, K ;

Itokawa, H .

JOURNAL OF NATURAL PRODUCTS, 1996, 59 (12) :1192-1195

[10] Ester-type cephalotaxus alkaloids from Cephalotaxus harringtonia var drupacea [J].

Takano, I ;

Yasuda, I ;

Nishijima, M ;

Yanagi, Y ;

Takeya, K ;

Itokawa, H .

PHYTOCHEMISTRY, 1997, 44 (04) :735-738

← 1 2 →