CAPILLARY ELECTROPHORESIS COUPLED TO MASS SPECTROMETRY (CE-MS): TWENTY YEARS OF DEVELOPMENT

被引:12
作者
Assuncao, Nilson Antonio [1 ]
Henriques Bechara, Etelvino Jose [1 ]
Colnaghi Simionato, Ana Valeria [2 ]
Maggi Tavares, Marina Franco [2 ]
Carrilho, Emanuel
机构
[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05513970 Sao Paulo, Brazil
[2] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05513970 Sao Paulo, Brazil
来源
QUIMICA NOVA | 2008年 / 31卷 / 08期
关键词
capillary electrophoresis; electrospray ionization; mass spectrometry;
D O I
10.1590/S0100-40422008000800037
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
CE-MS has been increasingly used for analysis of a vast array of compounds. This article reviews the different electrophoretic modes, interfaces and mass analyzers that are commonly used in the CE-MS coupling, as well as the technique advantages and performance characteristics. A large compilation of CE-MS applications is also presented. Therefore, this review is both a guide for beginners and a collection of key references for people who are familiar to the technique. Furthermore, this is the first CE-MS review published in a Brazilian journal and marks the installation of the first two commercial CE-MS units in Sao Paulo State.
引用
收藏
页码:2124 / 2133
页数:10
相关论文
共 163 条
[1]   Mass spectrometry-based proteomics [J].
Aebersold, R ;
Mann, M .
NATURE, 2003, 422 (6928) :198-207
[2]   Top-down analysis of basic proteins by microchip capillary electrophoresis mass spectrometry [J].
Akashi, Satoko ;
Suzuki, Koichi ;
Arai, Akihiro ;
Yamada, Naoyuki ;
Suzuki, Ei-Ichiro ;
Hirayama, Kazuo ;
Nakamura, Shin ;
Nishimura, Yoshifumi .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2006, 20 (12) :1932-1938
[3]   Separation and characterization of rabbit liver apothioneins by capillary electrophoresis coupled to electrospray ionization time-of-flight mass spectrometry [J].
Andon, Balbina ;
Barbosa, Jose ;
Sanz-Nebot, Victoria .
ELECTROPHORESIS, 2006, 27 (18) :3661-3670
[4]   Nonaqueous capillary electrophoresis in coated capillaries:: An interesting alternative for proteomic applications [J].
Assunçao, NA ;
Deziderio, LAG ;
Paulino, LG ;
Lupetti, KO ;
Carrilho, E .
ELECTROPHORESIS, 2005, 26 (17) :3292-3299
[5]   Selective sampling of multiply phosphorylated peptides by capillary electrophoresis for electrospray ionization mass spectrometry analysis [J].
Ballard, Jennifer N. M. ;
Lajoie, Gilles A. ;
Yeung, Ken K. -C. .
JOURNAL OF CHROMATOGRAPHY A, 2007, 1156 (1-2) :101-110
[6]   Recent advances in capillary electrophoresis electrospray mass spectrometry [J].
Banks, JF .
ELECTROPHORESIS, 1997, 18 (12-13) :2255-2266
[7]   State-of-the-art of the hyphenation of capillary electrochromatography with mass spectrometry [J].
Barceló-Barrachina, E ;
Moyano, E ;
Galceran, MT .
ELECTROPHORESIS, 2004, 25 (13) :1927-1948
[8]   Analysis and validation of the phosphorylated metabolites of two anti-human immunodeficiency virus nucleotides (stavudine and didanosine) by pressure-assisted CE-ESI-MS/MS in cell extracts: Sensitivity enhancement by the use of perfluorinated acids and alcohols as coaxial sheath-liquid make-up constituents [J].
Bezy, Vincent ;
Chaimbault, Patrick ;
Morin, Philippe ;
Unger, Steve E. ;
Bernard, Marie-Charlotte ;
Agrofoglio, Luigi A. .
ELECTROPHORESIS, 2006, 27 (12) :2464-2476
[9]   Determination of amphetamine-derived designer drugs in human urine by SPE extraction and capillary electrophoresis with mass spectrometry detection [J].
Boatto, G ;
Nieddu, M ;
Carta, A ;
Pau, A ;
Palomba, M ;
Asproni, B ;
Cerri, R .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2005, 814 (01) :93-98
[10]   Formation and efficacy of vancomycin group glycopeptide antibiotic stereoisomers studied by capillary electrophoresis and bioaffinity mass spectrometry [J].
Bonnici, PJ ;
Damen, M ;
Waterval, JCM ;
Heck, AJR .
ANALYTICAL BIOCHEMISTRY, 2001, 290 (02) :292-301