Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus

被引：131

作者：

Deng, Yong-Qiang ^{[1
,2
]}

Zhang, Na-Na ^{[1
,3
]}

Li, Chun-Feng ^{[4
,5
,6
]}

Tian, Min ^{[7
]}

Hao, Jia-Nan ^{[1
,8
]}

Xie, Xu-Ping ^{[9
]}

Shi, Pei-Yong ^{[9
]}

Qin, Cheng-Feng ^{[1
,2
,3
,8
]}

机构：

[1] Beijing Inst Microbiol & Epidemiol, Dept Virol, Beijing, Peoples R China

[2] State Key Lab Pathogen & Biosecur, Beijing, Peoples R China

[3] Guangxi Med Univ, Nanning, Peoples R China

[4] Chinese Acad Med Sci, Inst Basic Med Sci, Ctr Syst Med, Beijing, Peoples R China

[5] Peking Union Med Coll, Beijing, Peoples R China

[6] Suzhou Inst Syst Med, Suzhou, Jiangsu, Peoples R China

[7] Capital Med Univ, Beijing Tradit Med Chinese Hosp, Hefei, Peoples R China

[8] Anhui Med Univ, Hefei, Peoples R China

[9] Univ Texas Med Branch, Dept Pharmacol & Toxicol, Sealy Ctr Struct Biol & Mol Biophys, Dept Biochem & Mol Biol, Galveston, TX 77555 USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2016年 / 3卷 / 04期

关键词：

adenosine analog; antiviral; mouse model; Zika virus;

D O I：

10.1093/ofid/ofw175

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results have demonstrated that NITD008 is potent inhibitor of ZIKV and can be used as reference inhibitor for future ZIKV antiviral drug screen and discovery.

引用

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