Concise total syntheses of variolin B and deoxyvariolin B

被引：38

作者：

Anderson, RJ

Hill, JB

Morris, JC ^{[1
]}

机构：

[1] Univ Adelaide, Sch Chem & Phys, Adelaide, SA, Australia

[2] Univ Canterbury, Dept Chem, Christchurch 1, New Zealand

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 16期

关键词：

D O I：

10.1021/jo050523v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of the marine alkaloid variolin B has been achieved in 8 steps and 17% overall yield, starting from commercially available 4-chloro-2-methylthiopyrimidine. The key reaction involves the tandem deoxygenation and cyclization of a triarylmethanol using a combination of triethylsilane and trifluoroacetic acid. In addition, the deoxygenated analogue was prepared in 6 steps and 23% overall yield, starting from the same starting material.

引用

页码：6204 / 6212

页数：9

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