Pharmacokinetic/Toxicodynamic Analysis of Colistin-Associated Acute Kidney Injury in Critically Ill Patients

被引：70

作者：

Forrest, Alan ^{[1
,7
]}

Garonzik, Samira M. ^{[1
]}

Thamlikitkul, Visanu ^{[2
]}

Giamarellos-Bourboulis, Evangelos J. ^{[3
]}

Paterson, David L. ^{[4
]}

Li, Jian ^{[5
]}

Silveira, Fernanda P. ^{[6
]}

Nation, Roger L. ^{[5
]}

机构：

[1] Univ Buffalo SUNY, Sch Pharm & Pharmaceut Sci, Buffalo, NY 14260 USA

[2] Mahidol Univ, Fac Med, Div Infect Dis & Trop Med, Siriraj Hosp, Bangkok, Thailand

[3] Univ Athens, Med Sch, Dept Internal Med 4, Athens, Greece

[4] Univ Queensland, Royal Brisbane & Womens Hosp, Ctr Clin Res, Brisbane, Qld, Australia

[5] Monash Univ, Monash Inst Pharmaceut Sci, Drug Delivery Disposit & Dynam, Melbourne, Vic, Australia

[6] Univ Pittsburgh, Div Infect Dis, Pittsburgh, PA USA

[7] Univ N Carolina, Eshelman Sch Pharm, Div Pharmacotherapeut & Expt Therapy, Chapel Hill, NC USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 11期

关键词：

PK/TD relationship; acute kidney injury; colistin; POLYMYXIN-B; INTRAVENOUS COLISTIN; RENAL-FAILURE; RISK-FACTORS; NEPHROTOXICITY; COLISTIMETHATE; METHANESULFONATE; MULTICENTER; THERAPY; MODELS;

D O I：

10.1128/AAC.01367-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Acute kidney injury (AKI) occurs in a substantial proportion of critically ill patients receiving intravenous colistin. In the pharmacokinetic/toxicodynamic analysis reported here, the relationship of the occurrence of AKI to exposure to colistin and a number of potential patient factors was explored in 153 critically ill patients, none of whom were receiving renal replacement therapy. Tree-based modeling revealed that the rates of AKI were substantially higher when the average steady-state plasma colistin concentration was greater than similar to 2 mg/liter.

引用

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