7′,8′-Dihydroobolactone, a typanocidal α-pyrone from the rainforest tree Cryptocarya obovata

被引：33

作者：

Davis, Rohan A. ^{[1
]}

Demirkiran, Ozlem ^{[2
]}

Sykes, Melissa L. ^{[1
]}

Avery, Vicky M. ^{[1
]}

Suraweera, Lekha ^{[1
]}

Fechner, Gregory A. ^{[1
]}

Quinn, Ronald J. ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

[2] Trakya Univ, Fac Sci & Arts, Dept Chem, TR-22030 Edirne, Turkey

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 14期

关键词：

7; 8; '-Dihydroobolactone; Cryptocarya obovata; Antitrypanosomal; Trypanosoma brucei brucei; MCF-7; A549; HeLa; HEK293; TRYPANOSOMA-BRUCEI; FLAVONOIDS; ALKALOIDS; DRUG;

D O I：

10.1016/j.bmcl.2010.05.091

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mass-directed isolation of the CH(2)Cl(2)/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal alpha-pyrone, 7',8'-dihydroobolactone ( 1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7',8'-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 mu M. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4057 / 4059

页数：3

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