Antitrypanosomal pyridoacridine alkaloids from the Australian ascidian Polysyncraton echinatum

被引：33

作者：

Feng, Yunjiang ^{[1
]}

Davis, Rohan A. ^{[1
]}

Sykes, Melissa L. ^{[1
]}

Avery, Vicky M. ^{[1
]}

Carroll, Anthony R. ^{[1
]}

Camp, David ^{[1
]}

Quinn, Ronald J. ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 18期

关键词：

TRYPANOSOMA-BRUCEI; SLEEPING SICKNESS; FAMILY DIDEMNIDAE; NATURAL-PRODUCTS; TUNICATE; SPONGE; SHISHIDIDEMNIOLS; EFLORNITHINE; INHIBITORS;

D O I：

10.1016/j.tetlet.2010.02.161

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioassay-guided fractionation of the crude CH(2)Cl(2)/MeOH extract from the Australian ascidian Polysyncraton echinatum led to the isolation of a new pyridoacridine alkaloid, 12-deoxyascididemin (1), along with two known analogues, ascididemin (2) and eilatin (3). The structure of 1 was determined following extensive analysis of 1D/2D NMR and MS data. Biological evaluation showed that compounds 1-3 are potent antitrypanosomal agents with IC(50) values of 0.077, 0.032, and 1.33 mu M against Tryponosoma brucei brucei, respectively. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2477 / 2479

页数：3

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