Identification of blood microRNAs associated to Parkinsonis disease

被引：207

作者：

Margis, Regina ^{[2
,3
]}

Margis, Rogerio ^{[1
,3
]}

Rieder, Carlos R. M. ^{[2
]}

机构：

[1] Univ Fed Rio Grande do Sul, Ctr Biotechnol, Av Bento Goncalves 9500,Predio 43431,Sala 213,CxP, BR-91501970 Porto Alegre, RS, Brazil

[2] Hosp Clin Porto Alegre, Neurol Sect, Movement Disorders Unit, BR-9003500 Porto Alegre, RS, Brazil

[3] VITATEC Cons Des Biotecnol Ltda, BR-91010005 Porto Alegre, RS, Brazil

来源：

JOURNAL OF BIOTECHNOLOGY | 2011年 / 152卷 / 03期

关键词：

Parkinson's disease; MicroRNA; Neurodegenerative disease; RT-qPCR; Molecular marker; MINI-MENTAL-STATE; ALPHA-SYNUCLEIN; NEURODEGENERATIVE DISEASES; NEUROTROPHIC FACTOR; ALZHEIMERS-DISEASE; PROTEIN TPPP/P25; GENE-EXPRESSION; BRAIN; MECHANISM; TARGETS;

D O I：

10.1016/j.jbiotec.2011.01.023

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The present study demonstrates that blood samples can be used as a source of miRNA identification associated to Parkinson's disease (PD). A set of six differentially expressed microRNAs were identified. They form two groups according to their expression profile in control, non-treated, early-onset and treated Parkinson's disease subjects. While miR-1, miR-22* and miR-29 expression levels allowed to distinguish non-treated PD from healthy subjects, miR-16-2*, miR-26a2* and miR30a differentiated treated from untreated patients. This study is innovative in contributing to the development of effective PD biomarkers. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：96 / 101

页数：6

共 58 条

[1] The mini-mental state examination and the diagnosis of dementia in Brazil
Almeida, OP
[J]. ARQUIVOS DE NEURO-PSIQUIATRIA, 1998, 56 (3B) : 605 - 612
[2] The functions of animal microRNAs
Ambros, V
[J]. NATURE, 2004, 431 (7006) : 350 - 355
[3] Barbanti P, 1999, MOVEMENT DISORD, V14, P764, DOI 10.1002/1531-8257(199909)14:5<764::AID-MDS1008>3.0.CO
[4] 2-W
[5] Searching for MIND: MicroRNAs in Neurodegenerative Diseases
Barbato, Christian
Ruberti, Francesca
Cogoni, Carlo
[J]. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2009,
[6] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004)
Bartel, David P.
[J]. CELL, 2007, 131 (04) : 11 - 29
[7] MicroRNAs: Novel Biomarkers for Human Cancer
Bartels, Claudine L.
Tsongalis, Gregory J.
[J]. CLINICAL CHEMISTRY, 2009, 55 (04) : 623 - 631
[8] Batchelor PE, 1999, J NEUROSCI, V19, P1708
[9] AN INVENTORY FOR MEASURING DEPRESSION
BECK, AT
ERBAUGH, J
WARD, CH
MOCK, J
MENDELSOHN, M
[J]. ARCHIVES OF GENERAL PSYCHIATRY, 1961, 4 (06) : 561 - &
[10] The challenge of non-motor symptoms in Parkinson's disease
Bjorklund, Anders
Cenci, M. Angela
[J]. RECENT ADVANCES IN PARKINSONS DISEASE: TRANSLATIONAL AND CLINICAL RESEARCH, 2010, 184 : 325 - 341

← 1 2 3 4 5 6 →