EMT transcription factors in cancer development re-evaluated: Beyond EMT and MET

被引：365

作者：

Goossens, Steven ^{[1
,2
,3
]}

Vandamme, Niels ^{[1
,2
,4
]}

Van Vlierberghe, Pieter ^{[2
,3
]}

Berx, Geert ^{[1
,2
]}

机构：

[1] Univ Ghent, Dept Biomed Mol Biol, Mol Cellular Oncol Lab, Ghent, Belgium

[2] CRIG, Ghent, Belgium

[3] Univ Ghent, Ctr Med Genet, Ghent, Belgium

[4] VIB, IRC, Ghent, Belgium

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2017年 / 1868卷 / 02期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; SCHWANN-CELL DIFFERENTIATION; STEM-CELLS; E-CADHERIN; INDUCED APOPTOSIS; DEMETHYLASE LSD1; ACTIVATOR ZEB1; SELF-RENEWAL; TUMOR-GROWTH; KAPPA-B;

D O I：

10.1016/j.bbcan.2017.06.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Reactivation of an embryonic epithelial-to-mesenchymal (EMT) program is commonly accepted as a core component of carcinoma progression. Collectively, EMT and transcription factors (EMT-TFs) of the ZEB, SNAIL and TWIST families are quoted in the same breath for nearly 20 years. Recent work on these EMT-TFs has extended their scope, and their typical definition as EMT-inducing factors has become out-of-date. New insights have warranted a re-evaluation of these transcription factors and their pleiotropic functions in physiological and pathological conditions, not solely limited to cell invasion and dissemination.

引用

收藏

页码：584 / 591

页数：8

相关论文

共 104 条

[1]

LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells [J].

Adamo, Antonio ;

Sese, Borja ;

Boue, Stephanie ;

Castano, Julio ;

Paramonov, Ida ;

Barrero, Maria J. ;

Izpisua Belmonte, Juan Carlos .

NATURE CELL BIOLOGY, 2011, 13 (06) :652-U265

[2]

Role of the epithelial-mesenchymal transition regulator Slug in primary human cancers [J].

Alves, Catarina Castro ;

Carneiro, Fatima ;

Hoefler, Heinz ;

Becker, Karl-Friedrich .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2009, 14 :3041-3050

[3]

Angela Nieto, M. ;

Huang, Ruby Yun-Ju ;

Jackson, Rebecca A. ;

Thiery, Jean Paul .

CELL, 2016, 166 (01) :21-45

[4]

Epigenetic control of adult stem cell function [J].

Avgustinova, Alexandra ;

Benitah, Salvador Aznar .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2016, 17 (10) :643-658

[5]

Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells [J].

Barberà, MJ ;

Puig, I ;

Domínguez, D ;

Julien-Grille, S ;

Guaita-Esteruelas, S ;

Peiró, S ;

Baulida, J ;

Francí, C ;

Dedhar, S ;

Larue, L ;

de Herreros, AG .

ONCOGENE, 2004, 23 (44) :7345-7354

[6]

Tumor necrosis factor-α stimulates the epithelial-to-mesenchymal transition of human colonic organoids [J].

Bates, RC ;

Mercurio, AM .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (05) :1790-1800

[7]

Snail regulates cell survival and inhibits cellular senescence in human metastatic prostate cancer cell lines [J].

Baygi, Modjtaba Emadi ;

Soheili, Zahra Soheila ;

Schmitz, Ingo ;

Sameie, Shahram ;

Schulz, Wolfgang A. .

CELL BIOLOGY AND TOXICOLOGY, 2010, 26 (06) :553-567

[8]

Different Levels of Twist1 Regulate Skin Tumor Initiation, Stemness, and Progression [J].

Beck, Benjamin ;

Lapouge, Gaelle ;

Rorive, Sandrine ;

Drogat, Benjamin ;

Desaedelaere, Kylie ;

Delafaille, Stephanie ;

Dubois, Christine ;

Salmon, Isabelle ;

Willekens, Karen ;

Marine, Jean-Christophe ;

Blanpain, Cedric .

CELL STEM CELL, 2015, 16 (01) :67-79

[9]

Unravelling cancer stem cell potential [J].

Beck, Benjamin ;

Blanpain, Cedric .

NATURE REVIEWS CANCER, 2013, 13 (10) :727-738

[10]

Analysis of the E-cadherin repressor snail in primary human cancers [J].

Becker, K.-F. ;

Rosivatz, E. ;

Blechschmidt, K. ;

Kremmer, E. ;

Sarbia, M. ;

Hoefler, H. .

CELLS TISSUES ORGANS, 2007, 185 (1-3) :204-212

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