New cytotoxic oxygenated fucosterols from the brown alga Turbinaria conoides

被引：67

作者：

Sheu, JH ^{[1
]}

Wang, GH ^{[1
]}

Sung, PJ ^{[1
]}

Duh, CY ^{[1
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Resources, Kaohsiung 804, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 02期

关键词：

D O I：

10.1021/np980233s

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Fucosterol (1), 24 xi-hydroperoxy-24-vinylcholesterol (2), 29-hydroperoxystigmasta-5,24(28)-dien-3 beta-ol (3), 24-ethylcholesta-4,24(28)-dien-3-one (4), 24 xi-hydroperoxy-24-ethylcholesta-4,28(29) (5), 24-ethylcholesta-4,24(28)-dien-3,6-dione (6), 24 xi-hydroperoxy-24-ethylcholesta-4,28(29)(7), 6 beta-hydroxy-24-ethylcholesta-4, 24(28)-dien-3-one (8), and 24 xi-hydroperoxy-6 beta-hydroxy-24-ethylcholesta-4,-28(29)-dien-3-one (9) were isolated from the marine brown alga Turbinaria conoides. The structures of these compounds were established by spectral analysis. Isolated for the first time from a natural source, the oxygenated fucosterols 4-9 exhibit cytotoxicity against various cancer cell lines.

引用

页码：224 / 227

页数：4

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