Gut microbiome development along the colorectal adenoma-carcinoma sequence

被引：1002

作者：

Feng, Qiang ^{[1
,2
]}

Liang, Suisha ^{[1
,3
]}

Jia, Huijue ^{[1
]}

Stadlmayr, Andreas ^{[4
]}

Tang, Longqing ^{[1
]}

Lan, Zhou ^{[1
]}

Zhang, Dongya ^{[1
]}

Xia, Huihua ^{[1
]}

Xu, Xiaoying ^{[1
]}

Jie, Zhuye ^{[1
]}

Su, Lili ^{[1
]}

Li, Xiaoping ^{[1
]}

Li, Xin ^{[1
]}

Li, Junhua ^{[1
,3
,5
]}

Xiao, Liang ^{[1
]}

Huber-Schoenauer, Ursula ^{[4
]}

Niederseer, David ^{[4
]}

Xu, Xun ^{[1
]}

Al-Aama, Jumana Yousuf ^{[1
,6
]}

Yang, Huanming ^{[1
]}

Wang, Jian ^{[1
]}

Kristiansen, Karsten ^{[1
,2
]}

Arumugam, Manimozhiyan ^{[1
,7
]}

Tilg, Herbert ^{[8
]}

Datz, Christian ^{[4
]}

Wang, Jun ^{[1
,2
,6
,9
]}

机构：

[1] BGI Shenzhen, Shenzhen 518083, Peoples R China

[2] Univ Copenhagen, Dept Biol, DK-2200 Copenhagen, Denmark

[3] S China Univ Technol, Sch Biosci & Biotechnol, Guangzhou 510006, Guangdong, Peoples R China

[4] Paracelsus Private Univ Salzburg, Teaching Hosp, Hosp Oberndorf, Dept Internal Med, A-5110 Oberndorf, Austria

[5] BGI Hong Kong Res Inst, Hong Kong, Hong Kong, Peoples R China

[6] King Abdulaziz Univ, Princess Al Jawhara Ctr Excellence Res Hereditar, Jeddah 21589, Saudi Arabia

[7] Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark

[8] Med Univ Innsbruck, Dept Internal Med 1, A-6020 Innsbruck, Austria

[9] Macau Univ Sci & Technol, Taipa 999078, Macau, Peoples R China

来源：

NATURE COMMUNICATIONS | 2015年 / 6卷

关键词：

HEPARIN/HEPARAN SULFATE 2-O-SULFATASE; BILE-ACID; BACTEROIDES-THETAIOTAOMICRON; FLAVOBACTERIUM-HEPARINUM; METABOLISM; CANCER; BACTERIA; TUMORIGENESIS; INFLAMMATION; ASSOCIATIONS;

D O I：

10.1038/ncomms7528

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved in colorectal carcinogenesis. The identity and functional capacity of the adenoma-or carcinoma-related gut microbe(s), however, have not been surveyed in a comprehensive manner. Here we perform a metagenome-wide association study (MGWAS) on stools from advanced adenoma and carcinoma patients and from healthy subjects, revealing microbial genes, strains and functions enriched in each group. An analysis of potential risk factors indicates that high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. These findings suggest that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma.

引用

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