A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing

被引：99

作者：

Lange, Heiko ^{[1
]}

Carter, Catherine F. ^{[1
]}

Hopkin, Mark D. ^{[1
]}

Burke, Adrian ^{[2
]}

Goode, Jon G. ^{[3
]}

Baxendale, Ian R. ^{[1
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

[2] Mettler Toledo AutoChem Inc, Columbia, MD 21046 USA

[3] Mettler Toledo AutoChem UK, Leicester LE4 1AW, Leics, England

来源：

CHEMICAL SCIENCE | 2011年 / 2卷 / 04期

基金：

英国工程与自然科学研究理事会;

关键词：

REACTORS; MICROREACTORS; TOOL;

D O I：

10.1039/c0sc00603c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In order to use segmented chemical flow processing in more complex reaction sequences, a method has been developed to precisely control the addition of reagent streams during multi-step operations. Using in-line infra-red monitoring with a new LabVIEW software application, it is possible to control additional pumps to dispense further reagents in real time based upon the concentration of reaction intermediates. This enables precise mixing with perfect timing thus greatly increasing product quality and enabling segmented chemical flow processing to be used in extended reaction sequences.

引用

页码：765 / 769

页数：5

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