Versatile solid-phase synthesis of secondary amines from alcohols.: Development of an N-Boc-(o-nitrobenzene)sulfonamide linker

被引：9

作者：

Congreve, MS

Kay, C

Scicinski, JJ

Ley, SV

Williams, G

Murray, PJ

McKeown, SC

Watson, SP

机构：

[1] Univ Cambridge, GlaxoSmithKline, Cambridge CB2 1EW, England

[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[3] OSI Pharmaceut, Oxford OX4 6LT, England

[4] GlaxoSmithKline, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(03)00574-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The development of a versatile amine releasing linker based on the modified o-nitrobenzene sulfonamide protective group is described. This new N-Boc-o-nitrobenzenesulfonamide (Boc-ONBS) linker enables the elaboration on resin of primary and secondary amines by sequential substitution of the sulfonamide moiety using the Mitsunobu reaction. A 16-member array of secondary and Boc protected primary amines was then prepared using this linker. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：4153 / 4156

页数：4

共 13 条

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