Perhaloalkylation of Metal Enolates-Unconventional and Versatile

被引:19
作者
Amatov, Tynchtyk [1 ]
Jahn, Ullrich [1 ]
机构
[1] Acad Sci Czech Republic, Inst Organ Chem & Biochem, CR-16610 Prague 6, Czech Republic
关键词
electron transfer; enols; perhaloalkylation; radical reactions; valence tautomerism; CATALYZED TRIFLUOROMETHYLATION; ALPHA-TRIFLUOROMETHYLATION; PERFLUOROALKYLATION;
D O I
10.1002/anie.201007672
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Radically unconventional: Natural products with di- and trichloromethyl groups and trifluoromethylated pharmaceuticals and agrochemicials are interesting compounds, often with intriguing properties. These types of compounds can be prepared by the direct perhaloalkylation of carbonyl compounds in which enolate reactivity and radical reactivity are merged (see scheme; Bn=benzyl). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:4542 / 4544
页数:3
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