Stereoselective reduction of keto esters with marine micro algae

被引：9

作者：

Ishihara, K ^{[1
]}

Nakajima, N

Yamaguchi, H

Hamada, H

Uchimura, Y

机构：

[1] Kyoto Univ, Dept Chem, Fushimi Ku, Kyoto 6128522, Japan

[2] Okayama Prefectural Univ, Dept Nutrit Sci, Okayama 7191197, Japan

[3] Kyoto Univ, Chem Res Inst, Uji, Kyoto 6110011, Japan

[4] Okayama Univ Sci, Dept Appl Sci, Okayama 7000005, Japan

[5] Ehime Prefectural Fisheries Expt Stn, Uwazima, Ehime 7980104, Japan

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2001年 / 15卷 / 1-3期

关键词：

marine micro algae; stereoselective reduction; keto ester; biocatalyst; phytoplankton;

D O I：

10.1016/S1381-1177(00)00247-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It was found that alpha- and beta -keto esters were converted to the corresponding hydroxy esters by marine micro algae. Ethyl 2-methyl-3-oxobutanoate was reduced by Nannochloropsis sp. to the anti-hydroxy ester with excellent diastereo- (synlanti = 1:99) and high enantioselectivity (anti > 99%, syn 98%). The stereocontrolled reduction of ethyl 3-methyl-2-oxobutanoate was' accomplished by Nannochloropsis sp. or Chaetoceros gracilis in the presence Of L-lactic acid as an additive. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：101 / 104

页数：4

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