In vivo blood flow imaging by a swept laser source based Fourier domain optical Doppler tomography

被引：77

作者：

Zhang, J ^{[1
]}

Chen, ZP

机构：

[1] Univ Calif Irvine, Beckman Laser Inst & Med Clin, Irvine, CA 92612 USA

[2] Univ Calif Irvine, Ctr Biomed Engn, Irvine, CA 92612 USA

来源：

OPTICS EXPRESS | 2005年 / 13卷 / 19期

关键词：

D O I：

10.1364/OPEX.13.007449

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

A swept source based Fourier domain optical Doppler tomography (FDODT) system was developed. The technique is based on a phase-resolved method where phase information was retrieved from the reconstructed complex fringe signals. The aliasing effects and artifacts caused by lateral scanning and sample movement were removed with a signal processing technique. The standard deviation of the phase shift of the system was reduced from 49 to 1.8 degrees with the signal processing method employed. Structural, Doppler and Doppler variance images of fluid flow through glass channels were quantified, and blood flow through vessels of chick chorioallantoic membrane (CAM) was demonstrated in vivo. (c) 2005 Optical Society of America.

引用

页码：7449 / 7457

页数：9

共 22 条

[1] Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography [J].

Cense, B ;

Nassif, NA ;

Chen, T ;

Pierce, M ;

Yun, SH ;

Park, BH ;

Bouma, BE ;

Tearney, GJ ;

de Boer, JF .

OPTICS EXPRESS, 2004, 12 (11) :2435-2447

[2] Optical coherence tomography using a frequency-tunable optical source [J].

Chinn, SR ;

Swanson, EA ;

Fujimoto, JG .

OPTICS LETTERS, 1997, 22 (05) :340-342

[3] Sensitivity advantage of swept source and Fourier domain optical coherence tomography [J].

Choma, MA ;

Sarunic, MV ;

Yang, CH ;

Izatt, JA .

OPTICS EXPRESS, 2003, 11 (18) :2183-2189

[4] MEASUREMENT OF INTRAOCULAR DISTANCES BY BACKSCATTERING SPECTRAL INTERFEROMETRY [J].

FERCHER, AF ;

HITZENBERGER, CK ;

KAMP, G ;

ELZAIAT, SY .

OPTICS COMMUNICATIONS, 1995, 117 (1-2) :43-48

[5]

Häusler G, 1998, J BIOMED OPT, V3, P21, DOI 10.1117/1.429899

[6] OPTICAL COHERENCE TOMOGRAPHY [J].

HUANG, D ;

SWANSON, EA ;

LIN, CP ;

SCHUMAN, JS ;

STINSON, WG ;

CHANG, W ;

HEE, MR ;

FLOTTE, T ;

GREGORY, K ;

PULIAFITO, CA ;

FUJIMOTO, JG .

SCIENCE, 1991, 254 (5035) :1178-1181

[7] Amplified, frequency swept lasers for frequency domain reflectometry and OCT imaging: design and scaling principles [J].

Huber, R ;

Wojtkowski, M ;

Taira, K ;

Fujimoto, JG ;

Hsu, K .

OPTICS EXPRESS, 2005, 13 (09) :3513-3528

[8] Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography [J].

Jiao, SL ;

Knighton, R ;

Huang, XR ;

Gregori, G ;

Puliafito, CA .

OPTICS EXPRESS, 2005, 13 (02) :444-452

[9] Spectral measurement of absorption by spectroscopic frequency-domain optical coherence tomography [J].

Leitgeb, R ;

Wojtkowski, M ;

Kowalczyk, A ;

Hitzenberger, CK ;

Sticker, M ;

Fercher, AF .

OPTICS LETTERS, 2000, 25 (11) :820-822

[10] Performance of fourier domain vs. time domain optical coherence tomography [J].

Leitgeb, R ;

Hitzenberger, CK ;

Fercher, AF .

OPTICS EXPRESS, 2003, 11 (08) :889-894

← 1 2 3 →