A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

被引：93

作者：

Smith, Catherine J. ^{[1
]}

Nikbin, Nikzad ^{[1
]}

Ley, Steven V. ^{[1
]}

Lange, Heiko ^{[1
]}

Baxendale, Ian R. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 06期

基金：

英国工程与自然科学研究理事会; 美国安德鲁·梅隆基金会;

关键词：

CHEMISTRY; MICROREACTORS; REARRANGEMENT; DERIVATIVES; POTENT; AZIDES; BATCH;

D O I：

10.1039/c0ob00815j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Having demonstrated in the preceding publication the flow synthesis of aryl azides, we describe here a general protocol for the in-line purification of these versatile intermediates. As part of this investigation, we evaluated the use of ReactIR 45m as a tool for real-time detection of hazardous azide contaminants. This azide synthesis and purification process was then incorporated into a multistep flow sequence to generate a small collection of 5-amino-4-cyano-1,2,3-triazoles directly from aniline starting materials in a fully automated fashion.

引用

页码：1938 / 1947

页数：10

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