RNA Interference in Fungi: Pathways, Functions, and Applications

被引：154

作者：

Dang, Yunkun ^{[1
]}

Yang, Qiuying ^{[1
]}

Xue, Zhihong ^{[1
]}

Liu, Yi ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Physiol, Dallas, TX 75390 USA

来源：

EUKARYOTIC CELL | 2011年 / 10卷 / 09期

基金：

美国国家卫生研究院;

关键词：

DOUBLE-STRANDED-RNA; NEUROSPORA-CRASSA; UNPAIRED DNA; ASPERGILLUS-NIDULANS; CRYPTOCOCCUS-NEOFORMANS; CAENORHABDITIS-ELEGANS; MUCOR-CIRCINELLOIDES; MAGNAPORTHE-ORYZAE; SILENCING PATHWAY; FILAMENTOUS FUNGI;

D O I：

10.1128/EC.05109-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Small RNA molecules of about 20 to 30 nucleotides function in gene regulation and genomic defense via conserved eukaryotic RNA interference (RNAi)-related pathways. The RNAi machinery consists of three core components: Dicer, Argonaute, and RNA-dependent RNA polymerase. In fungi, the RNAi-related pathways have three major functions: genomic defense, heterochromatin formation, and gene regulation. Studies of Schizosaccharomyces pombe and Neurospora, and other fungi have uncovered surprisingly diverse small RNA biogenesis pathways, suggesting that fungi utilize RNAi-related pathways in various cellular processes to adapt to different environmental conditions. These studies also provided important insights into how RNAi functions in eukaryotic systems in general. In this review, we will discuss our current understanding of the fungal RNAi-related pathways and their functions, with a focus on filamentous fungi. We will also discuss how RNAi can be used as a tool in fungal research.

引用

页码：1148 / 1155

页数：8

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