Gut microbiota: a potential new territory for drug targeting

被引：376

作者：

Jia, Wei ^{[1
,2
]}

Li, Houkai ^{[1
,2
]}

Zhao, Liping ^{[1
,2
]}

Nicholson, Jeremy K. ^{[3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Inst Syst Biomed, Shanghai 200240, Peoples R China

[3] Univ London Imperial Coll Sci Technol & Med, Dept Biomol Med, Div Surg Oncol Reprod Biol & Anaesthet, Fac Med, London SW7 2AZ, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2008年 / 7卷 / 02期

关键词：

D O I：

10.1038/nrd2505

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The significant involvement of the gut microbiota in human health and disease suggests that manipulation of commensal microbial composition through combinations of antibiotics, prebiotics and prebiotics could be a novel therapeutic approach. A systems perspective is needed to help understand the complex host bacteria interactions and their association with pathophysiological phenotypes so that alterations in the composition of the gut microbiota in disease states can be reversed. In this article, we describe the therapeutic rationale and potential for targeting the gut microbiota, and discuss strategies and systems-oriented technologies for achieving this goal.

引用

页码：123 / 129

页数：7

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