Pd-Catalyzed α-Arylation of Nitriles and Esters and γ-Arylation of Unsaturated Nitriles with TMPZnCl•LiCl

被引：60

作者：

Duez, Stephanie ^{[2
]}

Bernhardt, Sebastian ^{[2
]}

Heppekausen, Johannes ^{[2
]}

Fleming, Fraser F. ^{[1
]}

Knocher, Paul ^{[2
]}

机构：

[1] Duquesne Univ, Dept Chem & Biochem, Pittsburgh, PA 15282 USA

[2] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 07期

基金：

欧洲研究理事会;

关键词：

ARYL BROMIDES; SELECTIVE MONOARYLATION; FUNCTIONALIZED ARENES; DIRECTED ZINCATION; CARBONYL-COMPOUNDS; GENERAL-METHOD; ZINC AMIDE; PALLADIUM; METALATION; BASE;

D O I：

10.1021/ol200194y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using TMPZnCl center dot"LiCl as a kinetically highly active base, nitriles and esters undergo a Pd-catalyzed alpha-arylation under mild conditions. Remarkably, in the case of alpha,beta or beta,gamma-unsaturated nitriles, a regioselective gamma-arylation or a gamma-alkenylation is observed.

引用

页码：1690 / 1693

页数：4

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