Synthesis and application to asymmetric allylic animation of substituted monodonor diazaphospholidine ligands

被引：21

作者：

Edwards, CW

Shipton, MR

Alcock, NW

Clase, H

Wills, M

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] GlaxoSmithKline Pharmaceut PLC, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON | 2003年 / 59卷 / 34期

关键词：

asymmetric; catalyst; ligand; allylic; substitution; amination;

D O I：

10.1016/S0040-4020(03)01062-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a series of substituted monodonor diazaphospholidine ligands is described. A regioselective lithiation on process is a key step in one of these syntheses. The compounds are designed to be incorporated into soluble polymer and other solid phase supports. Enantiomeric excesses of up to 88% were observed when these compounds were employed in palladium-catalysed asymmetric amination reactions. (C) 2003 Elsevier Ltd. All rights reserved.

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收藏

页码：6473 / 6480

页数：8

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