Radiative transport-based frequency-domain fluorescence tomography

被引：62

作者：

Joshi, Amit ^{[1
]}

Rasmussen, John C. ^{[1
]}

Sevick-Muraca, Eva M. ^{[1
]}

Wareing, Todd A. ^{[2
]}

McGhee, John ^{[2
]}

机构：

[1] Baylor Coll Med, Dept Radiol, Div Mol Imaging, Houston, TX 77030 USA

[2] Transpire Inc, Gig Harbor, WA USA

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2008年 / 53卷 / 08期

关键词：

D O I：

10.1088/0031-9155/53/8/005

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We report the development of radiative transport model- based fluorescence optical tomography from frequency-domain boundary measurements. The coupled radiative transport model for describing NIR fluorescence propagation in tissue is solved by a novel software based on the established Attila (TM) particle transport simulation platform. The proposed scheme enables the prediction of fluorescence measurements with non-contact sources and detectors at a minimal computational cost. An adjoint transport solution-based fluorescence tomography algorithm is implemented on dual grids to efficiently assemble the measurement sensitivity Jacobian matrix. Finally, we demonstrate fluorescence tomography on a realistic computational mouse model to locate nM to mu M fluorophore concentration distributions in simulated mouse organs.

引用

页码：2069 / 2088

页数：20

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