The bioinorganic and medicinal chemistry of carboranes: from new drug discovery to molecular imaging and therapy

被引：283

作者：

Armstrong, Andrea F.

Valliant, John F.

机构：

[1] McMaster Univ, Dept Chem, Hamilton, ON L8S 4M1, Canada

[2] McMaster Univ, Dept Med Phys, Hamilton, ON L8S 4M1, Canada

[3] McMaster Univ, Dept Appl Radiat Sci, Hamilton, ON L8S 4M1, Canada

来源：

DALTON TRANSACTIONS | 2007年 / 38期

关键词：

DICARBA-CLOSO-DODECABORANE; ANDROGEN RECEPTOR ANTAGONISTS; MICROWAVE-ASSISTED SYNTHESIS; CYCLOTRON PRODUCTION; POLYBORANE REACTIONS; POTENTIAL AGENTS; IN-VITRO; DERIVATIVES; METALLABORANES; ORGANOBORANES;

D O I：

10.1039/b709843j

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The role of carboranes in medicinal chemistry has diversified in recent years and now extends into areas of drug discovery, molecular imaging, and targeted radionuclide therapy. An introduction to carborane chemistry is provided to familiarize the non-expert with some key properties of these molecules, followed by an overview of current medicinally-orientated research involving carboranes. The broad-ranging nature of this research is illustrated, with emphasis placed on recent highlights and advances in this field.

引用

收藏

页码：4240 / 4251

页数：12

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