The role of double hydrogen bonds in asymmetric direct aldol reactions catalyzed by amino amide derivatives

被引：67

作者：

Chen, Xiao-Hua

Yu, Jie

Gong, Liu-Zhu ^{[1
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 35期

基金：

中国国家自然科学基金;

关键词：

L-PROLINAMIDE DERIVATIVES; PROTONIC ACID CATALYSTS; DIELS-ALDER REACTIONS; ENANTIOSELECTIVE ALDOL; DICARBOXYLIC-ACIDS; MOLECULAR RECOGNITION; CARBONYL-COMPOUNDS; ALIPHATIC-KETONES; ORGANIC-MOLECULES; TRANSITION-STATES;

D O I：

10.1039/c0cc00754d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The double hydrogen bonding activation of carbonyl functionality has been a general strategy for the design of amino amide organocatalysts for highly enantioselective direct aldol reactions of various ketones with aldehydes conducted in either organic solvents or aqueous media. Moreover, this concept may suggest an activation mode to create new catalysts for other related asymmetric transformations.

引用

收藏

页码：6437 / 6448

页数：12

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