Current development in microfluidic immunosensing chip

被引：172

作者：

Henares, Terence G. ^{[2
]}

Mizutani, Fumio ^{[2
]}

Hisamoto, Hideaki ^{[1
]}

机构：

[1] Osaka Prefecture Univ, Grad Sch Engn, Naka Ku, Sakai, Osaka 5998531, Japan

[2] Univ Hyogo, Grad Sch Med, Kamigori, Hyogo 6781297, Japan

来源：

ANALYTICA CHIMICA ACTA | 2008年 / 611卷 / 01期

关键词：

antibody; antigen; ELISA; immunoassay; microfluidics;

D O I：

10.1016/j.aca.2008.01.064

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This review accounts for the current development in microfluidic immunosensing chips. The basic knowledge of immunoassay in relation to its microfluidic material substrate, fluid handling and detection mode are briefly discussed. Here, we mainly focused on the surface modification, antibody immobilization, detection, signal enhancement and multiple analyte sensing. Some of the clinically important currently implemented on the microfluidic immunoassay chips are C-reactive protein (CRP), prostate specific antigen (PSA), ferritin, vascular endothelial growth factor (VEGF), myoglobin (Myo), cardiac troponin T (cTnT), cardiac troponin I (cTnI), and creatine kinase-cardiac muscle isoform (CK-MB). The emerging microfludic immunosensor technology may be a promising prospect that can propel the improvement of clinical and medical diagnosis. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：17 / 30

页数：14

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