A cationic zinc porphyrin as a chiroptical probe for Z-DNA

被引:116
作者
Balaz, M
De Napoli, M
Holmes, AE
Mammana, A
Nakanishi, K
Berova, N
Purrello, R
机构
[1] Columbia Univ, Dept Chem, New York, NY 10027 USA
[2] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy
关键词
chirality; circular dichroism; DNA; porphyrinoids; sensors;
D O I
10.1002/anie.200501149
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Z for zinc and Z-DNA: As a result of different binding modes, a cationic zinc porphyrin discriminates between B and Z conformations of DNA and holds promise as a probe for Z-DNA. A very intense induced circular dichroism (ICD) effect with a bisignate spectrum is observed upon interaction of the porphyrin with Z-DNA (see graphic; porphyrin red, Z-DNA green), whereas only a weak ICD spectrum results upon its interaction with B-DNA (Figure Presented). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:4006 / 4009
页数:4
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