Effects of hyperbaric oxygen preconditioning on energy metabolism and glutamate level in the peri-infarct area following permanent MCAO

被引：15

作者：

Cui Gao-Yu ^{[1
]}

Deng Cong-Yina ^{[2
]}

Zang Li-Jun ^{[1
]}

Li Fei ^{[1
]}

Feng Hua ^{[1
]}

机构：

[1] Third Mil Med Univ, Southwest Hosp, Dept Neurosurg, Chongqing, Peoples R China

[2] 324th Hosp PLA, Chongqing, Peoples R China

来源：

UNDERSEA AND HYPERBARIC MEDICINE | 2011年 / 38卷 / 02期

关键词：

CEREBRAL-ARTERY OCCLUSION; POSITRON-EMISSION-TOMOGRAPHY; RAT-BRAIN; INTRACEREBRAL MICRODIALYSIS; SUBARACHNOID HEMORRHAGE; ASCORBIC-ACID; ISCHEMIA; PYRUVATE; LACTATE; STROKE;

D O I：

暂无

中图分类号：

Q17 [水生生物学];

学科分类号：

071004 ;

摘要：

This study aimed to evaluate the effect of hyperbaric oxygen preconditioning (HBO2P) on ischemic metabolites and the glutamate level after permanent middle cerebral artery occlusion (MCAO). HBO2P was administered: five treatments, one treatment per day. The permanent rabbit MCAO models were induced by a modified transorbital approach. The microdialysis procedures were performanced in the right pen-infarct area and contralateral area. MCAO decreased glucose levels while increasing lactate, pyruvate and lactate/pyruvate ratios. Early increase of glycerol and glutamate were also shown. HBO2P stabilized the glucose level and decreased the lactate/pyruvate ratios and glycerol in the pen-infarct area. In addition, it inhibited the increase of the glutamate level. Our study demonstrated that MCAO led to the imbalance of brain energy metabolites and excitatory amino acids. The modulation of energy metabolism and glutamate may be one of the factors contributing to the neuroprotective property of HBO2P.

引用

页码：91 / 99

页数：9

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