Portrait of an immunoregulatory bifidobacterium

被引：107

作者：

Konieczna, Patrycja ^{[1
]}

Akdis, Cezmi A. ^{[1
]}

Quigley, Eamonn M. M. ^{[2
]}

Shanahan, Fergus ^{[2
]}

O'Mahony, Liam ^{[1
]}

机构：

[1] Univ Zurich, Swiss Inst Allergy & Asthma Res, Davos, Switzerland

[2] Univ Coll Cork, Natl Univ Ireland, Alimentary Pharmabiot Ctr, Cork, Ireland

来源：

GUT MICROBES | 2012年 / 3卷 / 03期

关键词：

microbiota; bifidobacteria; dendritic cells; immunoregulation; pattern recognition receptors; retinoic acid;

D O I：

10.4161/gmic.20358

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

There is increasing interest in the administration of microbes or microbial metabolites for the prevention and treatment of aberrant inflammatory activity. The protective effects associated with these microbes are mediated by multiple mechanisms involving epithelial cells, DCs and T cells, but most data are derived from animal models. In this addendum, we summarize our recent data, showing that oral consumption of Bifidobacterium infantis 35624 is associated with enhanced IL-10 secretion and Foxp3 expression in human peripheral blood. In addition, we discuss the potential DC subset-specific mechanisms, which could contribute to DCREG and TREG programming by specific gut microbes.

引用

页码：261 / 266

页数：6

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