MicroRNA-143 functions as a tumor suppressor in human bladder cancer T24 cells

被引：129

作者：

Noguchi, Syunsuke ^{[1
]}

Mori, Takashi ^{[2
,3
]}

Hoshino, Yuki ^{[2
,3
]}

Maruo, Kohji ^{[2
,3
]}

Yamada, Nami ^{[1
]}

Kitade, Yukio ^{[4
]}

Naoe, Tomoki ^{[5
]}

Akao, Yukihiro ^{[3
,4
]}

机构：

[1] Gifu Univ, United Grad Sch Vet Sci, Gifu 5011193, Japan

[2] Gifu Univ, Fac Appl Biol Sci, Gifu 5011193, Japan

[3] Gifu Univ, Comparat Canc Ctr, Gifu 5011193, Japan

[4] Gifu Univ, United Grad Sch Drug Discovery & Med Informat Sci, Gifu 5011193, Japan

[5] Nagoya Univ, Dept Hematol & Oncol, Grad Sch Med, Showa Ku, Nagoya, Aichi 4668550, Japan

来源：

CANCER LETTERS | 2011年 / 307卷 / 02期

关键词：

Bladder cancer; MicroRNA-143; Tumor suppressor; ERK5; Akt; RADICAL CYSTECTOMY; NATURAL-HISTORY; SURVIVAL; DEATH; BAD; PHOSPHORYLATION; CARCINOMA; THERAPY; PATHWAY; AND-145;

D O I：

10.1016/j.canlet.2011.04.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNA (miR)-143 and -145 were down-regulated in human bladder cancer T24 cells. The enforced expression of miR-143 induced growth-suppression in T24 cells through down-regulation of ERK5 and Akt expression at translational level, and chemically-modified synthetic miR-143 (miR-143/BP) exhibited a greater growth inhibitory effect than wild-type miR-143. In addition, the synthetic miR-143/BP induced apoptotic cell death in some of the transfected cells. Furthermore, co-treatment with the synthetic miR-143/BP and cisplatin showed the additive growth-suppressing effect on T24 cells. These findings suggest that the chemically-modified synthetic miR-143 functions as a tumor suppressor in 124 cells by targeting ERK5 and/or Akt. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：211 / 220

页数：10

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