Tetrabutylammonium bromide (TBAB) in isopropanol: An efficient, novel, neutral and recyclable catalytic system for the synthesis of 2,4,5-trisubstituted imidazoles

被引：119

作者：

Chary, Mahankhali Venu ^{[1
]}

Keerthysri, Nallani Chakravarthula ^{[1
]}

Vupallapati, Srinivasu V. N. ^{[1
]}

Lingaiah, N. ^{[1
]}

Kantevari, Srinivas ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 2, Fine Chem Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

CATALYSIS COMMUNICATIONS | 2008年 / 9卷 / 10期

关键词：

one-pot condensation; homogeneous catalysis; imidazole; benzil; ammonium acetate;

D O I：

10.1016/j.catcom.2008.03.037

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A simple, efficient and eco-friendly procedure has been developed using tetrabutylammonium bromide (TBAB, 10 mol%) as novel neutral ionic liquid catalyst for the synthesis of 2,4,5-triaryl imidazoles by a three-component, one-pot condensation of benzil, aryl aldehydes and ammonium acetate in refluxing isopropanol. The present methodology offers several advantages such as excellent yields, shorter reaction times (15-30 min) and environmentally benign milder reaction conditions: moreover, the catalyst in isoproparrol solvent exhibited reusable activity. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：2013 / 2017

页数：5

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