Deacetalisation-bicyclisation routes to novel polycyclic heterocycles using stannous chloride dihydrate

被引：16

作者：

Cayley, Alex N.

Cox, Rhona J.

Menard-Moyon, Cecilia

Schmidt, Jan Peter

Taylor, Richard J. K. ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[2] AstraZeneca R&D Charnwood, Med Chem, Loughborough LE11 5RH, Leics, England

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 37期

关键词：

heterocycles; stannous chloride; deacetalisation; bicyclisation;

D O I：

10.1016/j.tetlet.2007.07.018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stannous chloride dihydrate-mediated deprotection-bicyclisation of a range of amides possessing a pendant acetal group is reported. These mild reaction conditions have been used to prepare a number of ring-fused heterocyclic compounds, some in enantiomerically pure form, which should be of interest both in their own right and as building blocks for the production of more complex target molecules. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6556 / 6560

页数：5

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