Recent highlights in modified oligonucleotide chemistry

被引：83

作者：

Cobb, Alexander J. A. ^{[1
]}

机构：

[1] Univ Reading, Sch Pharm, Reading RG6 2AH, Berks, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 20期

关键词：

D O I：

10.1039/b709797m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of modified nucleic acids has been the subject of much study ever since the structure of DNA was elucidated by Watson and Crick at Cambridge and Wilkins and Franklin at King's College over half a century ago. This review describes recent developments in the synthesis and application of these artificial nucleic acids, predominantly the phosphoramidites which allow for easy inclusion into oligonucleotides, and is divided into three separate sections. Firstly, modi. cations to the base portion will be discussed followed secondly by modi. cations to the sugar portion. Finally, changes in the type of nucleic acid linker will be discussed in the third section. Peptide Nucleic Acids ( PNAs) are not discussed in this review as they represent a separate and large area of nucleic acid mimics.

引用

页码：3260 / 3275

页数：16

共 118 条

[101] Surfactant-type bronsted acid catalyzed dehydrative nucleophilic substitutions of alcohols in water [J].

Shirakawa, Seiji ;

Kobayashi, Shu .

ORGANIC LETTERS, 2007, 9 (02) :311-314

[102] Detecting RNA and DNA with templated chemical reactions [J].

Silverman, Adam P. ;

Kool, Eric T. .

CHEMICAL REVIEWS, 2006, 106 (09) :3775-3789

[103] LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition [J].

Singh, SK ;

Nielsen, P ;

Koshkin, AA ;

Wengel, J .

CHEMICAL COMMUNICATIONS, 1998, (04) :455-456

[104] A short, novel, and cheaper procedure for oligonucleotide synthesis using automated solid phase synthesizer [J].

Song, QL ;

Wang, ZW ;

Sanghvi, YS .

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2003, 22 (5-8) :629-633

[105] Synthesis and NMR-studies of dinucleotides with conformationally restricted cyclic phosphotriester linkages [J].

Sorensen, AM ;

Nielsen, KE ;

Vogg, B ;

Jacobsen, JP ;

Nielsen, P .

TETRAHEDRON, 2001, 57 (51) :10191-10201

[106] Synthesis of conformationally restricted dinucleotides by ring-closing metathesis [J].

Sorensen, AM ;

Nielsen, P .

ORGANIC LETTERS, 2000, 2 (26) :4217-4219

[107] α-L-ribo-configured locked nucleic acid (α-L-LNA):: Synthesis and properties [J].

Sorensen, MD ;

Kvaerno, L ;

Bryld, T ;

Håkansson, AE ;

Verbeure, B ;

Gaubert, G ;

Herdewijn, P ;

Wengel, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (10) :2164-2176

[108] Fluorescent pyrimidine ribonucleotide: Synthesis, enzymatic incorporation, and utilization [J].

Srivatsan, Seergazhi G. ;

Tor, Yitzhak .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (07) :2044-2053

[109] Syntheses of pyridine C-nucleosides as analogues of the natural nucleosides dC and dU [J].

Sun, Z ;

Ahmed, S ;

McLaughlin, LW .

JOURNAL OF ORGANIC CHEMISTRY, 2006, 71 (07) :2922-2925

[110] PRODAN-conjugated DNA: Synthesis and photochemical properties [J].

Tainaka, Kazuki ;

Tanaka, Kazuo ;

Ikeda, Shuji ;

Nishiza, Ken-ichiro ;

Unzai, Tomo ;

Fujiwara, Yoshimasa ;

Saito, Isao ;

Okamoto, Akimitsu .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (15) :4776-4784

← 3 4 5 6 7 8 9 10 11 12 →