Anti aldol selectivity in a synthetic approach to the C1-C12 fragment of the tedanolides

被引：13

作者：

Jung, Michael E. ^{[1
]}

Zhang, Ting-hu ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 01期

关键词：

D O I：

10.1021/ol702729u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In a synthetic approach to the completely protected C-1-C-12 fragment of the macrocyclic cytotoxic agent tedanolide 1, we carried out the tin-catalyzed Mukaiyama aldol reaction between the 2,3-dialkoxypropanal 5 and the silyl enol ether 6 derived from the ketone 7, which gave, unexpectedly, the anti aldol isomer, rather than the expected syn isomer 4, as the major diastereomer formed.

引用

页码：137 / 140

页数：4

共 27 条

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[16] JUNG ME, IN PRESS TETRAHEDRON
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