The IKMC web portal: a central point of entry to data and resources from the International Knockout Mouse Consortium

被引：67

作者：

Ringwald, Martin ^{[1
]}

Iyer, Vivek ^{[2
]}

Mason, Jeremy C. ^{[1
]}

Stone, Kevin R. ^{[1
]}

Tadepally, Hamsa D. ^{[1
]}

Kadin, James A. ^{[1
]}

Bult, Carol J. ^{[1
]}

Eppig, Janan T. ^{[1
]}

Oakley, Darren J. ^{[2
]}

Briois, Sebastien ^{[3
]}

Stupka, Elia ^{[4
]}

Maselli, Vincenza ^{[4
]}

Smedley, Damian ^{[5
]}

Liu, Songyan ^{[6
]}

Hansen, Jens ^{[7
]}

Baldock, Richard ^{[8
]}

Hicks, Geoff G. ^{[6
]}

Skarnes, William C. ^{[2
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

[2] Wellcome Trust Genome Campus, Sanger Inst, Cambridge CB10 1HH, England

[3] Univ Toulouse 3, CNRS, UMR 5088, LBCMCP, F-31062 Toulouse, France

[4] UCL, UCL Canc Inst, London WC1E 6BT, England

[5] Wellcome Trust Genome Campus, European Bioinformat Inst, Cambridge CB10 1SD, England

[6] Manitoba Inst Cell Biol, Winnipeg, MB R3E 0V9, Canada

[7] German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany

[8] Western Gen Hosp, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

NUCLEIC ACIDS RESEARCH | 2011年 / 39卷

基金：

美国国家卫生研究院;

关键词：

GENE; PROJECT; UPDATE;

D O I：

10.1093/nar/gkq879

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The International Knockout Mouse Consortium (IKMC) aims to mutate all protein-coding genes in the mouse using a combination of gene targeting and gene trapping in mouse embryonic stem (ES) cells and to make the generated resources readily available to the research community. The IKMC database and web portal (www.knockoutmouse.org) serves as the central public web site for IKMC data and facilitates the coordination and prioritization of work within the consortium. Researchers can access up-to-date information on IKMC knockout vectors, ES cells and mice for specific genes, and follow links to the respective repositories from which corresponding IKMC products can be ordered. Researchers can also use the web site to nominate genes for targeting, or to indicate that targeting of a gene should receive high priority. The IKMC database provides data to, and features extensive interconnections with, other community databases.

引用

页码：D849 / D855

页数：7

共 20 条

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