Spectral domain second-harmonic optical coherence tomography

被引：35

作者：

Sarunic, MV ^{[1
]}

Applegate, BE ^{[1
]}

Izatt, JA ^{[1
]}

机构：

[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

来源：

OPTICS LETTERS | 2005年 / 30卷 / 18期

关键词：

D O I：

10.1364/OL.30.002391

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Optical coherence tomography (OCT) provides micrometer-scale structural imaging by coherent detection of backscattered light. Molecular contrast in OCT has been demonstrated using transient absorption, coherent anti-Stokes Raman scattering, and second-harmonic (SH) generation. The sensitivity of molecular contrast signals can be enhanced by use of Fourier domain techniques. We have constructed a spectrometer-based Fourier domain SH-OCT system for simultaneous acquisition of the fundamental and SH signals. We report a > 30 dB increase in SH sensitivity over a similar time domain SH-OCT system and demonstrate contrast between cartilage and bone using collagen as the contrast agent. (c) 2005 Optical Society of America.

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收藏

页码：2391 / 2393

页数：3

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