Converting neXtProt into Linked Data and nanopublications

被引:10
作者
Chichester, Christine [1 ]
Karch, Oliver [2 ]
Gaudet, Pascale [1 ]
Lane, Lydie [1 ]
Mons, Barend [3 ]
Bairoch, Amos [1 ]
机构
[1] Swiss Inst Bioinformat, CALIPHO Grp, CH-1211 Geneva 4, Switzerland
[2] Merck Serono, Biomarker Technol, Discovery Bioinformat, D-64271 Darmstadt, Germany
[3] Netherlands Bioinformat Ctr, NL-6500 HB Nijmegen, Netherlands
关键词
Biological database; Linked Data; Semantic Web; nanopublication; post-translation modification; GENE ONTOLOGY; KNOWLEDGE; PROTEINS; RESOURCE; PLATFORM; CELLS;
D O I
10.3233/SW-140149
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
neXtProt provides a comprehensive knowledgebase on human proteins complemented by an extensive cross incorporation of annotations from many databases. With the diversity of published data, provenance information becomes critical to providing reliable and trustworthy services to scientists, thus the tracking of provenance in open, decentralized systems is especially important. Since the nanopublication system addresses many of these challenges, we have developed the neXtProt Linked Data by serializing in RDF/XML annotations specific to neXtProt and started employing the nanopublication model to give appropriate attribution to all data. Specifically, a use case demonstrates the handling of post-translational modification (PTM) data modeled as nanopublications to illustrate how the different levels of provenance and data quality thresholds can be captured in this model.
引用
收藏
页码:147 / 153
页数:7
相关论文
共 25 条
  • [1] Alexander K., 2009, LINK DAT WEB WORKSH
  • [2] [Anonymous], 2006, LINKED DATA WORLD WI
  • [3] [Anonymous], 2009, WORKSH SEM WEB APPL
  • [4] Gene Ontology: tool for the unification of biology
    Ashburner, M
    Ball, CA
    Blake, JA
    Botstein, D
    Butler, H
    Cherry, JM
    Davis, AP
    Dolinski, K
    Dwight, SS
    Eppig, JT
    Harris, MA
    Hill, DP
    Issel-Tarver, L
    Kasarskis, A
    Lewis, S
    Matese, JC
    Richardson, JE
    Ringwald, M
    Rubin, GM
    Sherlock, G
    [J]. NATURE GENETICS, 2000, 25 (01) : 25 - 29
  • [5] The Universal Protein Resource (UniProt) 2009
    Bairoch, Amos
    Consortium, UniProt
    Bougueleret, Lydie
    Altairac, Severine
    Amendolia, Valeria
    Auchincloss, Andrea
    Argoud-Puy, Ghislaine
    Axelsen, Kristian
    Baratin, Delphine
    Blatter, Marie-Claude
    Boeckmann, Brigitte
    Bolleman, Jerven
    Bollondi, Laurent
    Boutet, Emmanuel
    Quintaje, Silvia Braconi
    Breuza, Lionel
    Bridge, Alan
    deCastro, Edouard
    Ciapina, Luciane
    Coral, Danielle
    Coudert, Elisabeth
    Cusin, Isabelle
    Delbard, Gwennaelle
    Dornevil, Dolnide
    Roggli, Paula Duek
    Duvaud, Severine
    Estreicher, Anne
    Famiglietti, Livia
    Feuermann, Marc
    Gehant, Sebastian
    Farriol-Mathis, Nathalie
    Ferro, Serenella
    Gasteiger, Elisabeth
    Gateau, Alain
    Gerritsen, Vivienne
    Gos, Arnaud
    Gruaz-Gumowski, Nadine
    Hinz, Ursula
    Hulo, Chantal
    Hulo, Nicolas
    James, Janet
    Jimenez, Silvia
    Jungo, Florence
    Junker, Vivien
    Kappler, Thomas
    Keller, Guillaume
    Lachaize, Corinne
    Lane-Guermonprez, Lydie
    Langendijk-Genevaux, Petra
    Lara, Vicente
    [J]. NUCLEIC ACIDS RESEARCH, 2009, 37 : D169 - D174
  • [6] The GOA database in 2009-an integrated Gene Ontology Annotation resource
    Barrell, Daniel
    Dimmer, Emily
    Huntley, Rachael P.
    Binns, David
    O'Donovan, Claire
    Apweiler, Rolf
    [J]. NUCLEIC ACIDS RESEARCH, 2009, 37 : D396 - D403
  • [7] The Gene Ontology in 2010: extensions and refinements The Gene Ontology Consortium
    Berardini, Tanya Z.
    Li, Donghui
    Huala, Eva
    Bridges, Susan
    Burgess, Shane
    McCarthy, Fiona
    Carbon, Seth
    Lewis, Suzanna E.
    Mungall, Christopher J.
    Abdulla, Amina
    Wood, Valerie
    Feltrin, Erika
    Valle, Giorgio
    Chisholm, Rex L.
    Fey, Petra
    Gaudet, Pascale
    Kibbe, Warren
    Basu, Siddhartha
    Bushmanova, Yulia
    Eilbeck, Karen
    Siegele, Deborah A.
    McIntosh, Brenley
    Renfro, Daniel
    Zweifel, Adrienne
    Hu, James C.
    Ashburner, Michael
    Tweedie, Susan
    Alam-Faruque, Yasmin
    Apweiler, Rolf
    Auchinchloss, Andrea
    Bairoch, Amos
    Barrell, Daniel
    Binns, David
    Blatter, Marie-Claude
    Bougueleret, Lydie
    Boutet, Emmanuel
    Breuza, Lionel
    Bridge, Alan
    Browne, Paul
    Chan, Wei Mun
    Coudert, Elizabeth
    Daugherty, Louise
    Dimmer, Emily
    Eberhardt, Ruth
    Estreicher, Anne
    Famiglietti, Livia
    Ferro-Rojas, Serenella
    Feuermann, Marc
    Foulger, Rebecca
    Gruaz-Gumowski, Nadine
    [J]. NUCLEIC ACIDS RESEARCH, 2010, 38 : D331 - D335
  • [8] Carroll J.J., 2005, Proceedings of the 14th international conference on World Wide Web, P613, DOI [10.1145/1060745.1060835, DOI 10.1145/1060745.1060835]
  • [9] Chichester C., 2011, COLLABORATION SEMANT, P453
  • [10] The BioPAX community standard for pathway data sharing
    Demir, Emek
    Cary, Michael P.
    Paley, Suzanne
    Fukuda, Ken
    Lemer, Christian
    Vastrik, Imre
    Wu, Guanming
    D'Eustachio, Peter
    Schaefer, Carl
    Luciano, Joanne
    Schacherer, Frank
    Martinez-Flores, Irma
    Hu, Zhenjun
    Jimenez-Jacinto, Veronica
    Joshi-Tope, Geeta
    Kandasamy, Kumaran
    Lopez-Fuentes, Alejandra C.
    Mi, Huaiyu
    Pichler, Elgar
    Rodchenkov, Igor
    Splendiani, Andrea
    Tkachev, Sasha
    Zucker, Jeremy
    Gopinath, Gopal
    Rajasimha, Harsha
    Ramakrishnan, Ranjani
    Shah, Imran
    Syed, Mustafa
    Anwar, Nadia
    Babur, Oezguen
    Blinov, Michael
    Brauner, Erik
    Corwin, Dan
    Donaldson, Sylva
    Gibbons, Frank
    Goldberg, Robert
    Hornbeck, Peter
    Luna, Augustin
    Murray-Rust, Peter
    Neumann, Eric
    Reubenacker, Oliver
    Samwald, Matthias
    van Iersel, Martijn
    Wimalaratne, Sarala
    Allen, Keith
    Braun, Burk
    Whirl-Carrillo, Michelle
    Cheung, Kei-Hoi
    Dahlquist, Kam
    Finney, Andrew
    [J]. NATURE BIOTECHNOLOGY, 2010, 28 (09) : 935 - 942