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Synthesis of substituted quinolines by iron-catalyzed coupling reactions between chloroenynes and Grignard reagents

被引：36
作者：
Seck, M
Franck, X
Hocquemiller, R
Figadère, B
Peyrat, JF
Provot, O
Brion, JD
Alami, M
机构：
[1] Univ Paris Sud, Lab Pharmacognosie, Fac Pharm, F-92296 Chatenay Malabry, France
[2] Univ Paris Sud, Fac Pharm, BioCIS CNRS,UMR 8076, Chim Therapeut Lab, F-92296 Chatenay Malabry, France
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 09期
关键词：
Grignard reagents; iron; quinolines; anti-leishmania; enynes; vinyl chlorides;
D O I：
10.1016/j.tetlet.2004.01.019
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This letter reports the preparation of quinolines, substituted at the 2- or 3-position by a 4-substituted but-3-en-1-yne group, by the environmentally friendly iron (III)-catalyzed coupling reaction of Grignard reagents with 1-chloro-4-(2-quinolyl)but-1-en-3-yne. The extension and the scope of this non-toxic and chemoselective procedure to various functionalized unsaturated vinyl chlorides are described. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1881 / 1884
页数：4
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