Trigonosins A-F, Daphnane Diterpenoids from Trigonostemon thyrsoideum

被引：41

作者：

Li, Shi-Fei ^{[1
,2
]}

Di, Ying-Tong ^{[1
]}

Li, Shun-Lin ^{[1
]}

Zhang, Yu ^{[1
]}

Yang, Fu-Mei ^{[3
,4
]}

Sun, Qian-Yun ^{[3
,4
]}

Simo, James Mpetga ^{[1
]}

He, Hong-Ping ^{[1
]}

Hao, Xiao-Jiang ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[3] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China

[4] Chinese Acad Sci, Guiyang 550002, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 03期

关键词：

ASSAY; REIDIOIDES;

D O I：

10.1021/np1006444

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical study of the roots of Trigonostemon thyrsoideum led to the isolation of four new oxygenated daphnane-type diterpenoids, trigonosins A-D (1-4), and two new modified daphnanes, trigonosins E and F (S and 6). The structures and relative configurations were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments. All compounds isolated were evaluated for their cytotoxicity against HL-60, A549, and MCF-7 human cancer cell lines.

引用

页码：464 / 469

页数：6

共 15 条

[1]

ALLEY MC, 1988, CANCER RES, V48, P589

[2] Maprouneacin, a new daphnane diterpenoid with potent antihyperglycemic activity from Maprounea africana [J].

Carney, JR ;

Krenisky, JM ;

Williamson, RT ;

Luo, J ;

Carlson, TJ ;

Hsu, VL ;

Moswa, JL .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (02) :345-347

[3] Trigochinins A-C: Three New Daphnane-Type Diterpenes from Trigonostemon chinensis [J].

Chen, Hua-Dong ;

Yang, Sheng-Ping ;

He, Xiu-Feng ;

Ai, Jing ;

Liu, Zhen-Kai ;

Liu, Hong-Bing ;

Geng, Mei-Yu ;

Yue, Jian-Min .

ORGANIC LETTERS, 2010, 12 (06) :1168-1171

[4]

Evans F.J., 1983, Pro-Inflammatory, Tumour-Promoting and Anti-Tumour Diterpenes of the Plant Families Euphorbiaceae and Thymelaeaceae, P1

[5]

Gu Z.P., 1989, REPROD CONTRACEPT, V9, P48

[6] Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii [J].

He, WD ;

Cik, M ;

Lesage, A ;

Van der Linden, I ;

De Kimpe, N ;

Appendino, G ;

Bracke, J ;

Mathenge, SG ;

Mudida, FP ;

Leysen, JE ;

Van Puyvelde, L .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (09) :1185-1187

[7] Carboline Alkaloids from Trigonostemon lii [J].

Hu, Xu-Jia ;

Di, Ying-Tong ;

Wang, Yue-Hu ;

Kong, Ling-Yi ;

Gao, Suo ;

Li, Chun-Shun ;

Liu, Hai-Yang ;

He, Hong-Ping ;

Ding, Jian ;

Xie, Hua ;

Hao, Xiao-Jiang .

PLANTA MEDICA, 2009, 75 (10) :1157-1161

[8] New phenanthrenes from Trigonostemon lii YT Chang [J].

Hu, Xu-Jia ;

Wang, Yue-Hu ;

Kong, Ling-Yi ;

He, Hong-Ping ;

Gao, Suo ;

Liu, Hai-Yang ;

Ding, Jian ;

Xie, Hua ;

Di, Ying-Tong ;

Hao, Xiao-Jiang .

TETRAHEDRON LETTERS, 2009, 50 (24) :2917-2919

[9] Rediocides B-E, potent insecticides from Trigonostemon reidioides [J].

Jayasuriya, H ;

Zink, DL ;

Borris, RP ;

Nanakorn, W ;

Beck, HT ;

Balick, MJ ;

Goetz, MA ;

Gregory, L ;

Shoop, WL ;

Singh, SB .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (02) :228-231

[10] Structure and stereochemistry of rediocide A, a highly modified daphnane from Trigonostemon reidioides exhibiting potent insecticidal activity [J].

Jayasuriya, H ;

Zink, DL ;

Singh, SB ;

Borris, RP ;

Nanakorn, W ;

Beck, HT ;

Balick, MJ ;

Goetz, MA ;

Slayton, L ;

Gregory, L ;

Zakson-Aiken, M ;

Shoop, W ;

Singh, SB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (20) :4998-4999

← 1 2 →