Making sense of cancer genomic data

被引：223

作者：

Chin, Lynda ^{[1
,2
,3
]}

Hahn, William C. ^{[1
,2
,3
]}

Getz, Gad ^{[2
,3
]}

Meyerson, Matthew ^{[1
,2
,3
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Broad Inst Harvard, Cambridge, MA 02142 USA

[3] MIT, Cambridge, MA 02142 USA

来源：

GENES & DEVELOPMENT | 2011年 / 25卷 / 06期

关键词：

ARRAY CGH DATA; CONSENSUS CODING SEQUENCES; LINEAGE-SURVIVAL ONCOGENE; GROWTH-FACTOR RECEPTOR; TYROSINE KINASE JAK2; CELL LUNG-CANCER; GENE-EXPRESSION; COPY-NUMBER; HUMAN BREAST; SOMATIC MUTATIONS;

D O I：

10.1101/gad.2017311

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

High-throughput tools for nucleic acid characterization now provide the means to conduct comprehensive analyses of all somatic alterations in the cancer genomes. Both large-scale and focused efforts have identified new targets of translational potential. The deluge of information that emerges from these genome-scale investigations has stimulated a parallel development of new analytical frameworks and tools. The complexity of somatic genomic alterations in cancer genomes also requires the development of robust methods for the interrogation of the function of genes identified by these genomics efforts. Here we provide an overview of the current state of cancer genomics, appraise the current portals and tools for accessing and analyzing cancer genomic data, and discuss emerging approaches to exploring the functions of somatically altered genes in cancer.

引用

页码：534 / 555

页数：22

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