Carbon nanotubes as structural nanofibers for hyaluronic acid hydrogel scaffolds

被引：117

作者：

Bhattacharyya, Sanjib ^{[1
]}

Guillott, Samuel ^{[1
]}

Dabboue, Hinda ^{[1
]}

Tranchant, Jean-Francois ^{[2
]}

Salvetat, Jean-Paul ^{[1
]}

机构：

[1] Univ Penn, Dept Bioengn, Ctr Bioact Mat & Tissue Engn, Philadelphia, PA 19104 USA

[2] Parfums Christian Dior, Lab Physiochim, F-45804 St Jean De Braye, France

来源：

BIOMACROMOLECULES | 2008年 / 9卷 / 02期

关键词：

STEM-CELLS; ALGINATE; GEL; CHITOSAN; FUNCTIONALIZATION; SOLUBILIZATION; PROLIFERATION; TRANSPORTERS; CHEMISTRY; ADHESION;

D O I：

10.1021/bm7009976

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have successfully dispersed functionalized single-walled carbon nanotubes (SWNTs) within hyaluronic acid-water solutions. Hybrid hyaluronic acid (HA) hydrogels with SWNTs were then formed by cross-linking with divinyl sulfone. We have found a considerable change in the morphology of the lyophilized hybrid hydrogels compared to HA hydrogels. The high water uptake capacity, an important property of HA hydrogels, remained almost unchanged after 2 wt % SWNT (vs HA) incorporation, despite a dramatic enhancement in the dynamic mechanical properties of the hybrid hydrogels compared to native ones. We have found a 300% enhancement in the storage modulus of hybrid hydrogel with only 2 wt % of SWNTs vs HA (0.06 wt % vs total weight including water content). This apparent contradiction can be explained by a networking effect between SWNTs, mediated by HA chains. As in biological tissue, HA plays a dual role of matrix and linker for the rigid reinforcing nanofibers.

引用

页码：505 / 509

页数：5

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