Distinguishing possible mechanisms for auxin-mediated developmental control in Arabidopsis: Models with two Aux/IAA and ARF proteins, and two target gene-sets

被引：13

作者：

Bridge, L. J. ^{[1
]}

Mirams, G. R. ^{[3
]}

Kieffer, M. L. ^{[4
]}

King, J. R. ^{[2
]}

Kepinski, S. ^{[4
]}

机构：

[1] Univ Bath, Dept Math Sci, Bath BA2 7AY, Avon, England

[2] Univ Nottingham, Sch Math Sci, Nottingham NG7 2RD, England

[3] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 2JD, England

[4] Univ Leeds, Ctr Plant Sci, Leeds LS2 9JT, W Yorkshire, England

来源：

MATHEMATICAL BIOSCIENCES | 2012年 / 235卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Mathematical modelling; Gene regulatory networks; Auxin signalling; Developmental control; Bistability; FEEDBACK LOOPS; NETWORKS;

D O I：

10.1016/j.mbs.2011.10.005

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

New models of gene transcriptional responses to auxin signalling in Arabidopsis are presented. This work extends a previous model of auxin signalling to include networks of gene-sets which may control developmental responses along auxin gradients. Key elements of this new study include models of signalling pathways and networks involving two Aux-IAA proteins (IAAs), auxin response factors (ARFs) and gene targets. Hypotheses for the gene network topologies which may be involved in developmental responses have been tested against experimental observations for root hair growth in particular. In studying these models, we provide a framework for the analysis of auxin signalling with multiple IAAs and ARFs, and discuss the implications of bistability in such systems. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：32 / 44

页数：13

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