Design considerations of silicon nanowire biosensors

被引：238

作者：

Nair, Pradeep R. ^{[1
]}

Alam, Muhammad A. ^{[1
]}

机构：

[1] Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47907 USA

来源：

IEEE TRANSACTIONS ON ELECTRON DEVICES | 2007年 / 54卷 / 12期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

biosensors; DNA; Poisson-Boltzmann (PB); protein detection; random dopant fluctuations; sensitivity;

D O I：

10.1109/TED.2007.909059

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Biosensors based on silicon nanowires (Si-NWs) promise highly sensitive dynamic label-free electrical detection of biomolecules. Despite the tremendous potential and promising experimental results, the fundamental mechanism of electrical sensing of bioniolecules and the design considerations of NW sensors remain poorly understood. In this paper, we discuss the prospects and challenges of biomolecule detection using Si-NW biosensors as a function of device parameters, fluidic environment, charge polarity of biomolecules, etc., and refer to experimental results in literature to support the nonintuitive predictions wherever possible. Our results indicate that the design of Si nanobiosensor is nontrivial and as such, only careful optimization supported by numerical simulation would ensure optimal sensor performance.

引用

页码：3400 / 3408

页数：9

共 36 条

[11] Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species [J].

Cui, Y ;

Wei, QQ ;

Park, HK ;

Lieber, CM .

SCIENCE, 2001, 293 (5533) :1289-1292

[12] Integrated nanoscale silicon sensors using top-down fabrication [J].

Elibol, OH ;

Morisette, D ;

Akin, D ;

Denton, JP ;

Bashir, R .

APPLIED PHYSICS LETTERS, 2003, 83 (22) :4613-4615

[13] Anomalous resonance in a nanomechanical biosensor [J].

Gupta, Amit K. ;

Nair, Pradeep R. ;

Akin, Demir ;

Ladisch, Michael R. ;

Broyles, Steve ;

Alam, Muhammad A. ;

Bashir, Rashid .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (36) :13362-13367

[14] Direct ultrasensitive electrical detection of DNA and DNA sequence variations using nanowire nanosensors [J].

Hahm, J ;

Lieber, CM .

NANO LETTERS, 2004, 4 (01) :51-54

[15]

HAN SJ, 2006, IEDM, P719

[16] Computational aspects of the three-dimensional feature-scale simulation of silicon-nanowire field-effect sensors for DNA detection [J].

Heitzinger, Clemens ;

Klimeck, Gerhard .

JOURNAL OF COMPUTATIONAL ELECTRONICS, 2007, 6 (1-3) :387-390

[17]

Holst M, 1994, APPL MATH CRPC

[18] Model for the field effect from layers of biological macromolecules on the gates of metal-oxide-semiconductor transistors [J].

Landheer, D ;

Aers, G ;

McKinnon, WR ;

Deen, MJ ;

Ranuarez, JC .

JOURNAL OF APPLIED PHYSICS, 2005, 98 (04)

[19] Sequence-specific label-free DNA sensors based on silicon nanowires [J].

Li, Z ;

Chen, Y ;

Li, X ;

Kamins, TI ;

Nauka, K ;

Williams, RS .

NANO LETTERS, 2004, 4 (02) :245-247

[20] Silicon nanowires for sequence-specific DNA sensing: device fabrication and simulation [J].

Li, Z ;

Rajendran, B ;

Kamins, TI ;

Li, X ;

Chen, Y ;

Williams, RS .

APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 2005, 80 (06) :1257-1263

← 1 2 3 4 →