Acidic pH-Responsive Nanogels as Smart Cargo Systems for the Simultaneous Loading and Release of Short Oligonucleotides and Magnetic Nanoparticles

被引：48

作者：

Deka, Smriti R. ^{[1
]}

Quarta, Alessandra ^{[1
]}

Di Corato, Riccardo ^{[2
,3
]}

Falqui, Andrea ^{[1
]}

Manna, Liberato ^{[1
]}

Cingolani, Roberto ^{[1
]}

Pellegrino, Teresa ^{[1
,2
,3
]}

机构：

[1] Ist Italian Tecnol, I-16163 Genoa, Italy

[2] INFM, CNR, Nat Nanotechnol Lab, I-73100 Lecce, Italy

[3] IIT Res Unit, I-73100 Lecce, Italy

来源：

LANGMUIR | 2010年 / 26卷 / 12期

关键词：

IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY SYSTEMS; HYDROPHOBIC NANOCRYSTALS; MICROGEL PARTICLES; HYDROGELS; POLYMERS; DESIGN; CANCER; SEMICONDUCTOR; NANOCARRIERS;

D O I：

10.1021/la1004819

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Smart materials able to sense environmental stimuli can be exploited as intelligent carrier systems. Acidic pH-responsive polymers, for instance, exhibit a variation in the ionization state upon lowering the pH, which leads to their swelling. The different permeability of these polymers as a function of the pH could be exploited for the incorporation and subsequent release of previously trapped payload molecules/nanoparticles. We provide here a proof of concept of a novel use of pH-responsive polymer nanostructures based on 2-vinylpyridine and divinylbenzene, having an overall size below 200 nm, as cargo system for magnetic nanoparticles, for oligonucleotide sequences, as well as for their simultaneous loading and controlled release mediated by the pH.

引用

页码：10315 / 10324

页数：10

共 43 条

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