Palladium-catalyzed enantioselective oxidation of chiral secondary alcohols: Access to both enantiomeric series

被引：65

作者：

Ebner, David C. ^{[2
]}

Trend, Raissa M. ^{[2
]}

Genet, Cedric ^{[1
]}

McGrath, Matthew J. ^{[1
]}

O'Brien, Peter ^{[1
]}

Stoltz, Brian M. ^{[2
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[2] CALTECH, Div Chem & Chem Engn, Arnold & Mabel Beckman Labs Chem Synth, Pasadena, CA 91125 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 34期

基金：

英国工程与自然科学研究理事会;

关键词：

alcohols; asymmetric catalysis; oxidation; palladium; synthetic methods;

D O I：

10.1002/anie.200801865

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Rapid resolution: A new catalyst system for the oxidative kinetic resolution of secondary alcohols leads to dramatic rate increases. This system allows the use of a diamine to provide access to either enantiomer of a range of alcohols with good selectivity factors (see scheme). This method has been applied to the formal total synthesis of (-)-amurensinine. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6367 / 6370

页数：4

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