One-pot reductive mono-N-alkylation of aniline and nitroarene derivatives using aldehydes

被引：138

作者：

Byun, Eunyoung ^{[1
]}

Hong, Bomi ^{[1
]}

De Castro, Kathlia A. ^{[1
]}

Lim, Minkyung ^{[1
]}

Rhee, Hakjune ^{[1
]}

机构：

[1] Hanyang Univ, Dept Chem & Appl Chem, Ansan 426791, South Korea

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 25期

关键词：

D O I：

10.1021/jo701503q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[Graphics] One-pot reductive mono-N-alkylation of aniline and nitroarene derivatives using various aldehydes by Pd/C catalyst in aqueous 2-propanol solvent with ammonium formate as in situ hydrogen donor is illustrated. The reaction proceeded smoothly and selectively with excellent yield at room temperature. Our protocol presents a facile, economical, and environmentally benign alternative for reductive amination.

引用

页码：9815 / 9817

页数：3

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