Reactions of β-methoxyvinyl trifluoromethyl ketones with 2-pyridinecarboxamidrazone A convenient route to trifluoromethylated 4,5-dihydro-1H-1-picolinoylpyrazole hydrochlorides

被引：21

作者：

Bonacorso, HG ^{[1
]}

Lewandowski, H ^{[1
]}

Drekener, RL ^{[1
]}

Costa, MB ^{[1
]}

Pereira, CMP ^{[1
]}

Wastowski, AD ^{[1
]}

Peppe, C ^{[1
]}

Martins, MAP ^{[1
]}

Zanatta, N ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Quim, NUQUIMHE, BR-97105900 Santa Maria, RS, Brazil

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2003年 / 122卷 / 02期

关键词：

enones; amidrazones; pyrazoles; hydrochlorides; Cl-35; NMR;

D O I：

10.1016/S0022-1139(03)00057-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new series of six 3-aryl-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1-picolinoylpyrazole hydrochlorides were synthesised in one-step in high yields by the reaction of beta-methoxyvinyl trifluoromethyl ketones with 2-pyridinecarboxamidrazone in the presence of hydrochloric acid. The hydrochloride salts were easily converted to the respective new series of free trifluoromethylated 4,5-dihydro-1H-1-picolinoylpyrazoles using triethylamine in anhydrous diethyl ether. X-ray structure and Cl-35 NMR data from the pyrazole hydrochlorides are reported. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：159 / 163

页数：5

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