Metallacyclopeptides: Artificial analogues of naturally occurring peptides

被引：40

作者：

Albrecht, M ^{[1
]}

Stortz, P ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

CHEMICAL SOCIETY REVIEWS | 2005年 / 34卷 / 06期

关键词：

D O I：

10.1039/b405660d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Naturally occurring metalloproteins contain metal ions either to introduce a special reactivity or to stabilize a peptide structure. Since the early 1990s, chemists have been trying to use metal coordination for the fixation of short artificial peptides in well-defined cyclic structures. In this tutorial review a survey of the general approaches towards metallacyclopeptides as small cyclic peptide derivatives or as a part of a bigger alpha-helix (or beta-sheet) structure is given. In three case studies it is shown how naturally occurring compounds can be mimicked by metal coordination to non-natural peptide derivatives.

引用

页码：496 / 506

页数：11

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