Copper-Mediated Trifluoromethylation of Heteroaromatic Compounds by Trifluoromethyl Sulfonium Salts

被引：270

作者：

Zhang, Cheng-Pan ^{[1
]}

Wang, Zong-Ling ^{[2
]}

Chen, Qing-Yun ^{[1
]}

Zhang, Chun-Tao ^{[2
]}

Gu, Yu-Cheng ^{[3
]}

Xiao, Ji-Chang ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

[2] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China

[3] Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 08期

关键词：

copper; fluorine; heterocycles; sulfonium salts; trifluoromethylation; MILD ELECTROPHILIC TRIFLUOROMETHYLATION; MEDICINAL CHEMISTRY; AROMATIC-COMPOUNDS; ARYL HALIDES; IN-SITU; AGENTS; REAGENTS; FLUORINE; IODINE; (TRIFLUOROMETHYL)COPPER;

D O I：

10.1002/anie.201006823

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Copper is king! A convenient method for the synthesis of trifluoromethylated heteroaromatic compounds under mild conditions has been developed based on the observation that 1 can be reduced by certain metals (see scheme). Substrate 1 is assumed to be reduced by copper via a single-electron transfer mechanism, and CuCF3 is the most probable intermediate in this reaction. DMF=N,N-dimethylformamide, Tf=triflate. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1896 / 1900

页数：5

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